Mineral balance in infantile cortical hyperostosis: effects of corticosteroids.
نویسندگان
چکیده
The effects on mineral metabolism of therapeutic doses of corticosteroids were investigated in infantile cortical hyperostosis; in four untreated cases the calcium, phosphorus, and magnesium balances were strongly positive. In one severe case, treatment with prednisolone was associated with an alteration to negative calcium and magnesium balance, and faecal losses of calcium were particularly high. This effect persisted for at least three months after the steroids had been discontinued, and during this period there was pronounced retardation of linear growth. Six months after the treatment had been stopped mineral balance was again positive and there was rapid 'catch up' in growth. In infancy, the negative effect of corticosteroids on calcium, phosphorus, and magnesium metabolism may contribute to inhibition of bone growth and steroid stunting.
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1 Caffey J, Silverman W. Infantile cortical hyperostosis. Preliminary report in a new syndrome. AJR 1945;54:1. 2 Van Buskirk FW, Tampas JP, Peterson OS Jr. Infantile cortical hyperostosis. An enquiry into its familial aspects. AJR 1961;85:613. 3 Finsterbush A, Rang M. Infantile cortical hyperostosis. Followup of 29 cases. Acta Orthop Scand 1975;46:727. 4 Jackson DR, Lyne ED. Infantile cortical ...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 66 1 شماره
صفحات -
تاریخ انتشار 1991